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The European Medicines Agencys safety committee concluded that semaglutide, the active ingredient in Ozempic, Wegovy, and Rybelsus, may rarely cause non-arteritic anterior ischemic optic neuropathy (NAION)

There was another lab member who also showed signs of an allergy to peptide coupling agents, but caught it early and was able to manage it by limiting his use and having labmates weigh out the compound, McKnelly says

The peptide dosage calculator guide provides a practical reference for these conversions

Additional risks include diabetic retinopathy complications (particularly with semaglutide in patients with pre-existing retinopathy), acute kidney injury (especially with volume depletion from gastrointestinal effects), and rare cases of intestinal obstruction or ileus

The whispered logic was familiar: Everyone is doing it